HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethane, 2-diazo-1,1-diethoxy- → 16alpha-[(2,2-Diethoxy)ethoxy]-11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethane, 2-diazo-1,1-diethoxy- | HCID 21520892 | — |
| Reactant | 11beta,16alpha,17,21-Tetrahydroxy-6alpha-methylpregna-1,4-diene-3,20-dione | HCID 68129099 | — |
| Product | 16alpha-[(2,2-Diethoxy)ethoxy]-11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione | HCID 22791780 | — |
Reaction Steps
A solution of 2,2-diethoxy-1-diazoethane (prepared from 0.18 mole of precursor as described in Example 2A) in methanolether at 0°C is treated with 11β,16α,17,21-tetrahydroxy-6α-methylpregna-1,4-diene-3,20-dione, 16,17-cycloborate until nitrogen evolution ceases. The solution is evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-7f21642a8a214e3e94911cc69ec1c3ab |
| Source note | uspto-grants-1976_07 |