2-Methyl-2-thiopseudourea sulfate → Guanidine Sulfate (1:1)

HRID 918424Notes

Reaction equation

HRID 918424 reaction equation
ClC1C(CSCCN)=[N:4]C=CC=1.[S:13]([OH:17])([OH:16])(=[O:15])=[O:14].CS[C:20](=[NH:22])[NH2:21]>O>[S:13]([OH:17])([OH:16])(=[O:15])=[O:14].[NH2:21][C:20]([NH2:22])=[NH:4]

Participants

4

Reactant 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 129515322-(3-Chloropyrid-2-ylmethylthio)ethylamine

Product 1

HCID 499987Guanidine Sulfate (1:1)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-chloro-2-((2-aminoethyl)thiomethyl) pyridine (22.4 g) and S-methylisothiourea sulphate (15.1 g) in water (100 ml) was heated under reflux for 3 hours. Concentration, acidification with sulphuric acid and dilution with ethanol afforded 2-[3-chloro-2-pyridyl)methylthio)ethyl]guanidine sulphate.

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationConcentration, acidification with sulphuric acid and dilution with ethanol

Sources & evidence

ORD record
ord-38d538664abd48e3b581076a6522e159
Source dataset
uspto-grants-1976_07
Patent number
US03971786

Reaction notes

Loading…