1-Butylpiperidin-4-amine → N-(1-n-Butyl-4-piperidyl)-2-(7-chloro-4-quinolylamino)-3-methyl benzamide

HRID 918429Notes

Reaction equation

HRID 918429 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[C:21]([CH3:22])=[CH:20][CH:19]=[CH:18][C:14]=3[C:15](O)=[O:16])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[NH2:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:26][CH2:25]1>>[CH2:30]([N:27]1[CH2:28][CH2:29][CH:24]([NH:23][C:15](=[O:16])[C:14]2[CH:18]=[CH:19][CH:20]=[C:21]([CH3:22])[C:13]=2[NH:12][C:6]2[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:25][CH2:26]1)[CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 122628201-Butylpiperidin-4-amineHCID 536857712-(7-Chloro-4-quinolylamino)-3-methyl benzoic acid

Product 1

HCID 21521012N-(1-n-Butyl-4-piperidyl)-2-(7-chloro-4-quinolylamino)-3-methyl benzamide

Procedure

2-(7-Chloro-4-quinolylamino)-3-methyl benzoic acid is converted to the acid chloride which is reacted with 4-amino-1-n-butyl piperidine as in Example 1 to give the title compound.

Sources & evidence

ORD record
ord-f3cab131a6c14d7d95b6c6181f67dd16
Source dataset
uspto-grants-1976_07
Patent number
US03971789

Reaction notes

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