HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodobenzaldehyde → HCID 68120953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodobenzaldehyde | HCID 252610 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68120953 | HCID 68120953 | 60% |
Reaction Steps
A solution of 5.8 g of 3-iodobenzaldehyde, 4.4 g of γ-ethoxyacetoacetic acid ethyl ester and 3.3 g of β-aminocrotonic acid ethyl ester in 30 ml of ethanol is heated to the boil overnight and is then cooled. After cooling, 2-ethoxymethyl-6-methyl-4-(3'-iodophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in a yield of 60% of theory in the form of light yellow crystals which melt at 124°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971796 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-dbf1825e49bb419aa0ad74e354b50513 |
| Source note | uspto-grants-1976_07 |