Butylamine → HCID 54229225, compound

HRID 918459Notes

Reaction equation

HRID 918459 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]2[N:18]([CH2:19][CH3:20])[N:17]=[N:16][C:8]=2[C:9](OCC)=[N:10][C:11]=1[CH3:12])=[O:5])[CH3:2].[CH2:21]([NH2:25])[CH2:22][CH2:23][CH3:24]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]2[N:18]([CH2:19][CH3:20])[N:17]=[N:16][C:8]=2[C:9]([NH:25][CH2:21][CH2:22][CH2:23][CH3:24])=[N:10][C:11]=1[CH3:12])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 54080160HCID 54080160, compound

Product 1

HCID 54229225HCID 54229225, compoundYield 78%

Procedure

2.8 g. of 4-ethoxy-1-ethyl-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridine-7-carboxylic acid ethyl ester is treated for 14 hours with 10 ml. of n-butylamine at reflux temperature. The excess butylamine is distilled off and the residue of 4-butylamino-1-ethyl-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridine-7-carboxylic acid ethyl ester is recrystallized from petroleum ether, yield 78%, m.p. 85°-87°.

Workup

  1. distillationThe excess butylamine is distilled off
  2. customthe residue of 4-butylamino-1-ethyl-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridine-7-carboxylic acid ethyl ester is recrystallized from petroleum ether, yield 78%, m.p. 85°-87°

Sources & evidence

ORD record
ord-b0aa2849c85c4fba9cd0dd300c05cf52
Source dataset
uspto-grants-1976_07
Patent number
US03971800

Reaction notes

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