Acetone → HCID 86733763, compound

HRID 918461Notes

Reaction equation

HRID 918461 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]2[N:17]([CH2:18][CH3:19])[N:16]=[N:15][C:8]=2[C:9]([NH:13][NH2:14])=[N:10][C:11]=1[CH3:12])=[O:5])[CH3:2].[CH3:20][C:21]([CH3:23])=O>C(O)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:7]2[N:17]([CH2:18][CH3:19])[N:16]=[N:15][C:8]=2[C:9]([NH:13][N:14]=[C:21]([CH3:23])[CH3:20])=[N:10][C:11]=1[CH3:12])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 180AcetoneHCID 53701668HCID 53701668, compound

Product 1

HCID 86733763HCID 86733763, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidCatalyst

Procedure

2.6 g. of 1-ethyl-4-hydrazino-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridine-7-carboxylic acid ethyl ester (0.01 mol.) are dissolved in 10 ml. of acetone. One drop of acetic acid is added and the mixture is allowed to stand overnight. The excess acetone is distilled off in vacuo and the residue is recrystallized from petroleum ether to obtain 1-ethyl-6-methyl-4-[2-(1-methylethylidene)hydrazino]-1H-1,2,3-triazolo[4,5-c]pyridine-7-carboxylic acid ethyl ester in 95% yield, m.p. 68°-72°.

Workup

  1. distillationThe excess acetone is distilled off in vacuo
  2. customthe residue is recrystallized from petroleum ether

Sources & evidence

ORD record
ord-9feee9ee450448269aad083744e99a5b
Source dataset
uspto-grants-1976_07
Patent number
US03971800

Reaction notes

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