4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester → (2,5-Difluorophenyl)-{7-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl}-methanone

HRID 91847Notes

Reaction equation

HRID 91847 reaction equation
[CH3:22][N:23]1[CH2:24][CH2:25][N:26]([C:29](=[O:30])[c:31]2[cH:32][cH:33][c:34]([B:37]3[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]3)[cH:35][cH:36]2)[CH2:27][CH2:28]1.[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[c:12]3[c:13]([n:17][cH:18][c:19]([I:21])[cH:20]3)[NH:14][CH2:15][CH2:16]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1>>[F:1][c:2]1[c:3]([C:9](=[O:10])[N:11]2[c:12]3[c:13]([n:17][cH:18][c:19](-[c:34]4[cH:33][cH:32][c:31]([C:29]([N:26]5[CH2:25][CH2:24][N:23]([CH3:22])[CH2:28][CH2:27]5)=[O:30])[cH:36][cH:35]4)[cH:20]3)[NH:14][CH2:15][CH2:16]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27600304-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol esterHCID 57885852(2,5-difluorophenyl)-(7-iodo-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl)methanone

Product 1

HCID 57885964(2,5-Difluorophenyl)-{7-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl}-methanone

Sources & evidence

ORD record
ord-71baccd93e58485d84183444b2bddb50
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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