Isopropanol → HCID 21521117, compound

Participants

Reaction Conditions

Reaction Steps

40.5 g of 5-phenyl-1,3,4-oxadiazol-2-one (.25 mol) and 71 g of N,N-diethyl-dithiocarbamic acid (4-hydroxy-3,4-dimethylbenzyl) ester (0.25 mol) are dissolved in 500 ml of isopropanol at 60°C. After dropwise addition of 10 g of sodium hydroxide in 100 ml of water, the mixture is stirred for 9 hours at 60°C. The solvent is then largely evaporated off, the yellow residue is dissolved in acetonitrile, insoluble matter is filtered off and the mother liquor is again evaporated. The residue, which crystallises slowly, is recrystallised from methanol. 3-(3,5-Dimethyl-4-hydroxybenzyl)5-phenyl-1,3,4-oxadiazol-2-one (stabiliser No. 16) of melting point 135°C is thus obtained.

Provenance & Evidence