HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → Diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Reactant | Ethylideneacetoacetic acid ethyl ester | HCID 53428592 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | HCID 12391086 | 59% |
Reaction Steps
Upon heating a solution of 15.6 g of ethylideneacetoacetic acid ethyl ester and 13.0 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 2 hours, 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 140°C (isopropanol) is obtained. Yield: 59% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971791 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-d2a9535046184dd087a49a763478d4df |
| Source note | uspto-grants-1976_07 |