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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918499Generated: October 31, 2026

1,3-Cyclohexanedione → HCID 70635962, compound

https://huagongshe.com/reaction/918499

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-CyclohexanedioneHCID 10434—
Reactant6-Methyl-2-pyridinecarboxaldehydeHCID 70737—
ReactantCarbamimidoyl-acetic acid ethyl esterHCID 4599837—
ReactantN,N-dimethylformamide ethanolHCID 19794673—
SolventEthanolHCID 702—
ProductHCID 70635962HCID 7063596246%

Reaction Steps

Upon heating a solution of 4.8 g of 6-methylpyridin-2-aldehyde, 4.5 g of cyclohexane-1,3-dione and 5.2 g of amidinoacetic acid ethyl ester in 120 ml of ethanol for 8 hours, 2-amino-4-(6-methylpyrid-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point >260°C (ethanol/DMF) is obtained. Yield: 46% of theory.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03971791
Source datasetuspto-grants-1976_07
ORD IDord-420b6bc549d14bccae96396309e6c527
Source noteuspto-grants-1976_07