HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Amino-6-methyl-4-(2-cyanophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| Reactant | 2-Cyanobenzylideneacetoacetic acid ethyl ester | HCID 54316407 | — |
| Product | 2-Amino-6-methyl-4-(2-cyanophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester | HCID 70636168 | 58% |
Reaction Steps
Upon boiling a solution of 12.2 g of 2-cyanobenzylideneacetoacetic acid ethyl ester and 7.2 g of amidinoacetic acid isopropyl ester in 200 ml of ethanol for 1 hour, 2-amino-6-methyl-4-(2-cyanophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester of melting point 200°C (isopropanol) is obtained. Yield: 58% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971791 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-e52f77cfd2554abfaebc455f57d9b875 |
| Source note | uspto-grants-1976_07 |