HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1,3-Cyclohexanedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Amino-4-(2-trifluoromethyl-4-nitrophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester | HCID 12391113 | — |
| Product | 1,3-Cyclohexanedione | HCID 10434 | — |
| Product | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Product | 4-Nitro-2-(trifluoromethyl)benzaldehyde | HCID 12391105 | — |
Reaction Steps
Upon heating a solution of 11.0 g. of 2-trifluoromethyl-4-nitrobenzaldehyde, 5.6 g of cyclohexane-1,3-dione and 6.5 g of amidinoacetic acid ethyl ester in 250 ml of ethanol of 2 hours, 2-amino-4-(2-trifluoromethyl-4-nitrophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 264°C (ethanol) is obtained. Yield: 62% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971791 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-0408c0e5fa26414780825dd1a44f3ad9 |
| Source note | uspto-grants-1976_07 |