HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamimidoyl-acetic acid ethyl ester → 2-Amino-6-methyl-4-(1-naphthyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Reactant | (1-Naphthylidene)acetoacetic acid ethyl ester | HCID 70607594 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-6-methyl-4-(1-naphthyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70603293 | 62% |
Reaction Steps
Boiling a solution of 13.4 g of (1-naphthylidene)acetoacetic acid ethyl ester and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 8 hours yields 2-amino-6-methyl-4-(1-naphthyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 174°C (ethanol). Yield: 62% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971791 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-249ea34a5d5f49a0bae75009c097542c |
| Source note | uspto-grants-1976_07 |