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Ethanol → 2-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| 反応物 | Ethyl 2-nitrobenzylidene-acetoacetate | HCID 53923751 | — |
| 生成物 | 2-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester | HCID 70635117 | 39% |
反応手順
Boiling a solution of 13.2 g of 2-nitrobenzylideneacetoacetic acid ethyl ester and 7.2 g of amidinoacetic acid isopropyl ester in 100 ml of ethanol for 6 hours yields 2-amino-6-methyl-4-(2-nitrophenyl)-1,4-dihyropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester of melting point 139°C (isopropanol). Yield: 39% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03971791 |
| 出典データセット | uspto-grants-1976_07 |
| ORD ID | ord-ed61e4ff05004d45842f11098deef73f |
| 出典メモ | uspto-grants-1976_07 |