1,3-Cyclohexanedione → 2-Amino-4-(3-carbethoxyphenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,3-Cyclohexanedione	HCID 10434	—
Edukt	Carbamimidoyl-acetic acid ethyl ester	HCID 4599837	—
Edukt	Ethyl 3-formylbenzoate	HCID 11084437	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	2-Amino-4-(3-carbethoxyphenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester	HCID 12391116	54%

Reaktionsschritte

Upon heating a solution of 8.9 g of 3-carbethoxybenzaldehyde, 5.6 g of cyclohexane-1,3-dione and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 4 hours, 2-amino-4-(3-carbethoxyphenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 234°C (ethanol) is obtained. Yield: 54% of theory.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US03971791
Quelldatensatz	uspto-grants-1976_07
ORD ID	ord-2fec978ec9c144b69b6edee613ab91c6
Quellennotiz	uspto-grants-1976_07