HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrobenzaldehyde → 2-Amino-5-acetyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-5-acetyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester | HCID 12716938 | 48% |
Reaction Steps
Upon boiling a solution of 7.6 g of 3-nitrobenzaldehyde, 5.0 g of acetylacetone and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 2 hours, 2-amino-5-acetyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid ethyl ester of melting point 217°C (ethanol) is obtained. Yield: 48% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971790 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-c7227816b0ef4f2fb5bebbd700749323 |
| Source note | uspto-grants-1976_07 |