HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylidene-benzoylacetic acid ethyl ester → 2-Amino-4,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylidene-benzoylacetic acid ethyl ester | HCID 140230 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl ester | HCID 70635527 | 48% |
Reaction Steps
Upon boiling a solution of 14.0 g of benzylidenebenzoylacetic acid ethyl ester and 6.5 g of amidinoacetic acid ethyl ester in 150 ml of ethanol for 2 hours, 2-amino-4,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl ester of melting point 183°C (ethanol) is obtained. Yield: 48% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971790 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-d48ee1e9dff54bbbb290a9fa9b9619ff |
| Source note | uspto-grants-1976_07 |