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HRID918525

反应详情

EQUATION

反应方程式

HRID 918525 的结构方程式

REACTANTS

反应物

4
结构：O=C1CCCC(=O)C1
HCID10434

1,3-Cyclohexanedione

C6H8O2

结构：Cc1cccc(C=O)n1
HCID70737

6-Methyl-2-pyridinecarboxaldehyde

C7H7NO

结构：CCOC(=O)CC(=N)N
HCID4599837

Carbamimidoyl-acetic acid ethyl ester

C5H10N2O2

结构：CCO.CN(C)C=O
HCID19794673

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(N)NC2=C(C(=O)CCC2)C1c1cccc(C)n1
HCID70635962

未命名化合物

收率 46%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Upon heating a solution of 4.8 g of 6-methylpyridin-2-aldehyde, 4.5 g of cyclohexane-1,3-dione and 5.2 g of amidinoacetic acid ethyl ester in 120 ml of ethanol for 8 hours, 2-amino-4-(6-methylpyrid-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point >260°C (ethanol/DMF) is obtained. Yield: 46% of theory.