Methanol → 1-Amino-5-methoxyanthracene-9,10-dione

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Reaction Steps

40 parts by volume of methanol and 10 parts of sodium hydroxide are dissolved at the boil and 13.3 parts of 1-aminoanthraquinone-5-sulphonic acid are introduced into this solution at 80°C, over the course of 30 minutes, with vigorous stirring. The mixture is now stirred for a further 3 hours at 80°-85°C until only traces of starting material are still present according to chromatography. The mixture is now diluted with 50 parts of hot water and the product is filtered off, washed with boiling hot water until neutral and dried at 100°-120°C. 8.9 parts of 1-amino-5-methoxy-anthraquinone (80% of theory) are obtained.

Provenance & Evidence