HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918602Generated: November 3, 2026
Phenol → 5-Dimethylsulphamyl-3-nitro-4-phenoxy-benzoic acid
https://huagongshe.com/reaction/918602
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Chloro-5-dimethylsulphamyl-3-nitro-benzoic acid | HCID 21506054 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Dimethylsulphamyl-3-nitro-4-phenoxy-benzoic acid | HCID 21505999 | — |
Reaction Steps
A mixture of 4-chloro-5-dimethylsulphamyl-3-nitro-benzoic acid (3.08 g), phenol (2 g), sodium hydrogen carbonate (3.4 g), and water (20 ml) was heated at 90°C for 8 hours. Then water (40 ml) was added and, after cooling, the 5-dimethylsulphamyl-3-nitro-4-phenoxy-benzoic acid was precipitated by acidification with 4N hydrochloric acid. After isolation by filtration and several recrystallizations from ethanol, the said compound was obtained with a melting point of 224°-226°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03971819 |
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| Source dataset | uspto-grants-1976_07 |
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| ORD ID | ord-620fe651c61f4f868f9e86a0c92a335c |
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| Source note | uspto-grants-1976_07 |
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