HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918632Generated: October 31, 2026
Hydrochloric Acid → 3-Nitro-4-piperidino-5-sulphamyl-benzoic acid
https://huagongshe.com/reaction/918632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Chloro-3-nitro-5-sulphamoylbenzoic acid | HCID 89893 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Nitro-4-piperidino-5-sulphamyl-benzoic acid | HCID 21506107 | — |
Reaction Steps
A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (2.8 g), piperidine (3.4 g), and water (13 ml) was stirred at 95°C for 2 hours. Then the reaction mixture was adjusted to a pH of 2.5 by the addition of 4N hydrochloric acid, and the precipitated 3-nitro-4-piperidino-5-sulphamyl-benzoic acid was collected and recrystallized from aqueous methanol. The melting point was 237°-238°C (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03971819 |
|---|
| Source dataset | uspto-grants-1976_07 |
|---|
| ORD ID | ord-4c02ae6e4b664b3fb69e8f972b5d5623 |
|---|
| Source note | uspto-grants-1976_07 |
|---|
