Hydrochloric Acid → HCID 21312193, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ammonium chloride (2.4 g), metallic iron powder (24 g), concentrated hydrochloric acid (0.1 ml), and water (60 ml) was heated to 90°C with stirring, and 3-nitro-4-phenylthio-5-sulphamyl-benzoic acid (10 g) was added in small portions during 2 hours. The reaction mixture was stirred on a steam bath for an additional 2 hours. After the addition of dilute sodium hydroxide until the pH was 8, the hot reaction mixture was filtered, and the filter-cake was washed with warm dilute sodium hydroxide. After the addition of 4N hydrochloric acid to the filtrate until its pH was 2 and cooling, the resulting precipitate, consisting of 3-amino-4-phenylthio-5-sulphamyl-benzoic acid, was filtered off and dried at 78°C in vacuo. The melting point was 285°C.

Provenance & Evidence