Ammonia → 3-Nitro-4-phenoxy-5-sulphamyl-benzamide

HRID 918652Notes

Reaction equation

HRID 918652 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].[NH3:24]>>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:20](=[O:23])(=[O:22])[NH2:21])[C:12]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]([NH2:24])=[O:8])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 215060353-Nitro-4-phenoxy-5-sulfamoylbenzoyl chloride

Product 1

HCID 215060723-Nitro-4-phenoxy-5-sulphamyl-benzamide

Procedure

3-Nitro-4-phenoxy-5-sulphamyl-benzoyl chloride (4 g) was added in portions to liquid ammonia (40 ml). Then excess of ammonia was distilled off, and the residue was triturated with water (50 ml). The precipitated 3-nitro-4-phenoxy-5-sulphamyl-benzamide was isolated by filtration and recrystallized twice from aqueous ethanol. After drying in vacuo, the compound was obtained with a melting point of 255°-256°C.

Workup

  1. distillationThen excess of ammonia was distilled off
  2. customthe residue was triturated with water (50 ml)

Sources & evidence

ORD record
ord-b5fd12e597c945a384442a5e7f92d1d4
Source dataset
uspto-grants-1976_07
Patent number
US03971819

Reaction notes

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