Ethanol → HCID 21506026, compound

Participants

Reaction Steps

A mixture of 3-amino-4-morpholino-5-sulphamyl-benzoic acid (3 g), benzyl bromide (4 g), and anhydrous ethanol (45 ml) was refluxed. After 24 hours and again after 48 hours a solution of benzyl bromide (1.5 g) in anhydrous ethanol (5 ml) was added during 4 hours. After the second addition, the refluxing was continued for 24 hours. The reaction mixture was cooled, and the precipitated ethyl 3-benzylamino-4-morpholino-5-sulphamyl-benzoate was collected by suction and recrystallized from ethanol, after which the compound was obtained with a melting point of 185-186°C.

Provenance & Evidence