Ethyl 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoate → 3-Benzylamino-5-methylsulphamyl-4-phenoxy-benzoic acid

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Reaction Steps

Ethyl 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoate (0.5 g) was dissolved in 1N sodium hydroxide (8 ml) and heated on a steam bath for 1 hour. After cooling, the 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoic acid was precipitated by addition of 4N hydrochloric acid until a pH of 2.5. The precipitate was collected by suction and recrystallized from aqueous ethanol. After drying in vacuo, the melting point of the compound was 231-233°C.

Provenance & Evidence