Ethyl 3-benzylamino-5-dimethylsulphamyl-4-phenoxy-benzoate → 3-Benzylamino-5-(n-butylsulphamyl)-4-phenoxy-benzoic acid

HRID 918696Notes

Reaction equation

HRID 918696 reaction equation
[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:17]=[C:18]([S:27](=[O:34])(=[O:33])[NH:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:19]=1[O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:12]([O:14]CC)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NC1C=C(C=C(S(=O)(=O)N(C)C)C=1OC1C=CC=CC=1)C(OCC)=O)C1C=CC=CC=1>>[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:17]=[C:18]([S:27](=[O:34])(=[O:33])[NH:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:19]=1[O:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21506051Ethyl 3-benzylamino-5-dimethylsulphamyl-4-phenoxy-benzoateHCID 21506077HCID 21506077, compound

Product 1

HCID 215060973-Benzylamino-5-(n-butylsulphamyl)-4-phenoxy-benzoic acid

Procedure

By substituting in step B above ethyl 3-benzylamino-5-(n-butylsulphamyl)-4-phenoxy-benzoate for the ethyl 3-benzylamino-5-dimethylsulphamyl-4-phenoxy-benzoate, and after recrystallization from ethanol, the aove compound was obtained with a melting point of 212°C.

Workup

  1. customafter recrystallization from ethanol
  2. customthe aove compound was obtained with a melting point of 212°C.

Sources & evidence

ORD record
ord-0cec027ad1b5443484e96da42ef6b1ac
Source dataset
uspto-grants-1976_07
Patent number
US03971819

Reaction notes

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