Pyridine → HCID 131730604, compound

HRID 918764Notes

Reaction equation

HRID 918764 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:29])([F:28])[F:27])[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=3)[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.ClC1C=C[C:34]([C:35](Cl)=[O:36])=CN=1.[N:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1.C(Cl)[Cl:47]>>[Cl:47][C:45]1[N:40]=[CH:41][C:42]([CH2:34][C:35]([NH:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][C:9]([C:4]4[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=4)([C:26]([F:29])([F:28])[F:27])[CH2:10]3)=[CH:15][C:16]=2[C:22]([F:23])([F:24])[F:25])=[O:36])=[CH:43][CH:44]=1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27821656-Chloronicotinoyl ChlorideHCID 59453382HCID 59453382, compound

Product 1

HCID 131730604HCID 131730604, compound

Procedure

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine (0.1 g) and 6-chloronicotinic acid chloride (0.04 g) were dissolved in methylene chloride (5 mL), and then pyridine (0.03 g) was added thereto. The resulting mixture was stirred at room temperature for one hour. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (0.1 g).

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. customthe residue was then purified by a column chromatography

Sources & evidence

ORD record
ord-12dec7615c6340958af75a8559742ac1
Source dataset
uspto-grants-2016_03
Patent number
US09271499B2

Reaction notes

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