4-tert-Butylbenzylamine → HCID 118113917, compound

HRID 918827Notes

Reaction equation

HRID 918827 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Br:13][C:14]1[CH:15]=[CH:16][C:17]2[N:18]([CH:20]=[C:21]([C:23](OCC)=[O:24])[N:22]=2)[CH:19]=1>>[Br:13][C:14]1[CH:15]=[CH:16][C:17]2[N:18]([CH:20]=[C:21]([C:23]([NH:12][CH2:11][C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=3)=[O:24])[N:22]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 27356554-tert-ButylbenzylamineHCID 7141939Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 118113917HCID 118113917, compound

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate I, using (4-(tert-butyl)phenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials. 1H NMR (400 MHz, CDCl3) δ 9.53 (s, 1H), 8.60 (s, 1H), 8.41 (s, 1H), 7.88 (d, 1H), 7.79 (d, 1H), 7.36 (d, 2H), 7.32 (d, 2H), 4.60 (d, 2H), 1.38 (s, 9H). MS 385.9, 387.9 (M+1)+.

Sources & evidence

ORD record
ord-95e3a924d2b44626be2625145913e66b
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

Loading…