(5-Bromo-2-methoxy-phenyl)-[4-(2,4-difluoro-phenylamino)-phenyl]-methanone → [4-(2,4-Difluoroanilino)phenyl]-[5-[2-(4-hydroxy-1-methylpiperidin-4-yl)ethenyl]-2-methoxyphenyl]methanone

HRID 91883Notes

Reaction equation

HRID 91883 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:25][CH3:26])[c:6]([C:8](=[O:9])[c:10]2[cH:11][cH:12][c:13]([NH:16][c:17]3[c:18]([F:24])[cH:19][c:20]([F:23])[cH:21][cH:22]3)[cH:14][cH:15]2)[cH:7]1.[CH3:27][N:28]1[CH2:29][CH2:30][C:31]([OH:34])([CH:35]=[CH:36][Sn:37]([CH2:38][CH2:39][CH2:40][CH3:41])([CH2:42][CH2:43][CH2:44][CH3:45])[CH2:46][CH2:47][CH2:48][CH3:49])[CH2:32][CH2:33]1>>[c:2]1([CH:36]=[CH:35][C:31]2([OH:34])[CH2:30][CH2:29][N:28]([CH3:27])[CH2:33][CH2:32]2)[cH:3][cH:4][c:5]([O:25][CH3:26])[c:6]([C:8](=[O:9])[c:10]2[cH:11][cH:12][c:13]([NH:16][c:17]3[c:18]([F:24])[cH:19][c:20]([F:23])[cH:21][cH:22]3)[cH:14][cH:15]2)[cH:7]1

Participants

3

Reactant 2

HCID 22349575(5-Bromo-2-methoxy-phenyl)-[4-(2,4-difluoro-phenylamino)-phenyl]-methanoneHCID 685360831-Methyl-4-(2-tributylstannylethenyl)piperidin-4-ol

Product 1

HCID 69554501[4-(2,4-Difluoroanilino)phenyl]-[5-[2-(4-hydroxy-1-methylpiperidin-4-yl)ethenyl]-2-methoxyphenyl]methanone

Sources & evidence

ORD record
ord-18227125be9049fca436cee8806da5ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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