3-Chloro-4-fluorobenzylamine → 6-Bromo-N-(3-chloro-4-fluorobenzyl)imidazo[1,2-a]pyridine-2-carboxamide

HRID 918836Notes

Reaction equation

HRID 918836 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH2:10])[CH:5]=[CH:6][C:7]=1[F:8].[Br:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16]([CH:18]=[C:19]([C:21](OCC)=[O:22])[N:20]=2)[CH:17]=1>>[Br:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16]([CH:18]=[C:19]([C:21]([NH:10][CH2:9][C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=3)=[O:22])[N:20]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 1445393-Chloro-4-fluorobenzylamineHCID 7141939Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 1181138816-Bromo-N-(3-chloro-4-fluorobenzyl)imidazo[1,2-a]pyridine-2-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate I, using (3-chloro-4-fluorophenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

Sources & evidence

ORD record
ord-2df7565088664e48b689f82c74f6c848
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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