4-Isopropylbenzylamine → 6-Bromo-N-(4-isopropylbenzyl)imidazo[1,2-a]pyridine-2-carboxamide

HRID 918838Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[C:20]([C:22](OCC)=[O:23])[N:21]=2)[CH:18]=1>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[C:20]([C:22]([NH:11][CH2:10][C:7]3[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=3)=[O:23])[N:21]=2)[CH:18]=1

Participants

Reactant 2

HCID 1382214-Isopropylbenzylamine

HCID 7141939Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 1181139466-Bromo-N-(4-isopropylbenzyl)imidazo[1,2-a]pyridine-2-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate I, using (4-isopropylphenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

Sources & evidence

ORD record: ord-c9d35595ea1f4502ab0988e53e80beb1
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09271969B2

Reaction notes

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