3-Chloro-4-fluorobenzylamine → 2-Bromo-N-(3-chloro-4-fluorobenzyl)imidazo[2,1-b]thiazole-6-carboxamide

HRID 918867Notes

Reaction equation

HRID 918867 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH2:10])[CH:5]=[CH:6][C:7]=1[F:8].[Br:11][C:12]1[S:16][C:15]2=[N:17][C:18]([C:20](O)=[O:21])=[CH:19][N:14]2[CH:13]=1>>[Br:11][C:12]1[S:16][C:15]2=[N:17][C:18]([C:20]([NH:10][CH2:9][C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=3)=[O:21])=[CH:19][N:14]2[CH:13]=1

Participants

3

Reactant 2

HCID 1445393-Chloro-4-fluorobenzylamineHCID 127446152-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

Product 1

HCID 1181139392-Bromo-N-(3-chloro-4-fluorobenzyl)imidazo[2,1-b]thiazole-6-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using (3-chloro-4-fluorophenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-3c2620c9ff97432c9c569b823c947009
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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