2-Fluoro-5-(trifluoromethoxy)benzylamine → 2-Bromo-N-(2-fluoro-5-(trifluoromethoxy)benzyl)imidazo[2,1-b]thiazole-6-carboxamide

HRID 918869Notes

Reaction equation

HRID 918869 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[CH2:13][NH2:14].[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24](O)=[O:25])=[CH:23][N:18]2[CH:17]=1>>[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24]([NH:14][CH2:13][C:3]3[CH:4]=[C:5]([O:8][C:9]([F:11])([F:12])[F:10])[CH:6]=[CH:7][C:2]=3[F:1])=[O:25])=[CH:23][N:18]2[CH:17]=1

Participants

3

Reactant 2

HCID 37393022-Fluoro-5-(trifluoromethoxy)benzylamineHCID 127446152-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

Product 1

HCID 1181139362-Bromo-N-(2-fluoro-5-(trifluoromethoxy)benzyl)imidazo[2,1-b]thiazole-6-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using (2-fluoro-5-(trifluoromethoxy)phenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-1a181661a7224b2abb085616cd1cbf58
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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