2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid → HCID 118113919, compound

HRID 918872Notes

Reaction equation

HRID 918872 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1([NH2:12])[CH2:11][CH2:10]1.[Br:13][C:14]1[S:18][C:17]2=[N:19][C:20]([C:22](O)=[O:23])=[CH:21][N:16]2[CH:15]=1>>[Br:13][C:14]1[S:18][C:17]2=[N:19][C:20]([C:22]([NH:12][C:9]3([C:3]4[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=4[F:1])[CH2:10][CH2:11]3)=[O:23])=[CH:21][N:16]2[CH:15]=1

Participants

3

Reactant 2

HCID 127446152-Bromoimidazo[2,1-b]thiazole-6-carboxylic acidHCID 45791187HCID 45791187, compound

Product 1

HCID 118113919HCID 118113919, compound

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using 1-(2,5-difluorophenyl)cyclopropanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-602eb43aa925430b8067d6f114ba990e
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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