2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid → HCID 118113909, compound

HRID 918877Notes

Reaction equation

HRID 918877 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][C:3]=1[O:10][C:11]([F:14])([F:13])[F:12].[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24](O)=[O:25])=[CH:23][N:18]2[CH:17]=1>>[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24]([NH:9][CH2:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[C:3]([O:10][C:11]([F:13])([F:12])[F:14])[CH:4]=3)=[O:25])=[CH:23][N:18]2[CH:17]=1

Participants

3

Reactant 2

HCID 127446152-Bromoimidazo[2,1-b]thiazole-6-carboxylic acidHCID 177507021-[4-Fluoro-3-(trifluoromethoxy)phenyl]methanamine

Product 1

HCID 118113909HCID 118113909, compound

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate XLIV, using (4-fluoro-3-(trifluoromethoxy)phenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-31158f92c77247e587e0cd55ab51c844
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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