1-(2-Methoxyphenyl)piperazine → HCID 76901442, compound

HRID 918959Notes

Reaction equation

HRID 918959 reaction equation
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([Cl:14])[CH:10]=[C:9]([Cl:15])[C:3]=1[O:4][CH2:5][CH:6]1[CH2:8][O:7]1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>C(O)C>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][N:27]([CH2:8][CH:6]([OH:7])[CH2:5][O:4][C:3]2[C:9]([Cl:15])=[CH:10][C:11]([Cl:14])=[C:12]([Cl:13])[C:2]=2[Cl:1])[CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 118558303HCID 118558303, compound

Product 1

HCID 76901442HCID 76901442, compoundYield 44.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-((2,3,4,6-tetrachlorophenoxy)methyl)oxirane (45 mg, 0.16 mmol) in ethanol (0.50 mL) was added 4-(2-methoxyphenyl)piperazine (33 μL, 0.19 mmol) at room temperature. The mixture was stirred under reflux for 1 hr. The reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give HUHS1007 (34 mg, 44%).

Workup

  1. temperatureunder reflux for 1 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customThe crude product was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-3c109637590f4bf89a77b66dd8c7e8e9
Source dataset
uspto-grants-2016_03
Patent number
US09272980B2

Reaction notes

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