HRID918978

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID559019

2-(4-Bromobutoxy)tetrahydro-2H-pyran

C9H17BrO2

结构：C#CCCCCCCCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

HCID85784253

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](OCCCCCCCCCCC#CCCCCOC1CCCCO1)(c1ccccc1)c1ccccc1

HCID53309395

未命名化合物

收率 66%

PROCEDURE

实验过程

Alkylation of 12-(tert-butyldiphenylsilyloxy)dodec-1-yne with 2-(4-bromobutoxy)tetrahydropyran as described above gave tert-butyldiphenyl-[16-(tetrahydropyran-2-yloxy)hexadec-11-ynyloxy]silane (66%) as a colorless oil which was used in the next reaction without further purification. TLC: 10% EtOAc/hexane, Rf≈0.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7b1419e508ef496ba8fcca332cd759cd
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09272991B2
来源说明: uspto-grants-2016_03

反应 SMILES

[Si:1]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]#[CH:30])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:32][CH2:33][CH2:34][CH2:35][O:36][CH:37]1[CH2:42][CH2:41][CH2:40][CH2:39][O:38]1>>[C:14]([Si:1]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]#[C:30][CH2:32][CH2:33][CH2:34][CH2:35][O:36][CH:37]1[CH2:42][CH2:41][CH2:40][CH2:39][O:38]1)([CH3:15])([CH3:16])[CH3:17]