HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromododecane → 2-(pentadec-2-ynyloxy)tetrahydro-2H-pyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromododecane | HCID 8919 | — |
| Reactant | Tetrahydro-2-(2-propynyloxy)-2H-pyran | HCID 98609 | — |
| Product | 2-(pentadec-2-ynyloxy)tetrahydro-2H-pyran | HCID 67423329 | 80% |
Reaction Steps
Alkylation of 2-(prop-2-ynyloxy)tetrahydro-2H-pyran (15.5 g, 110.71 mmol) with 1-bromododecane (34.0 g, 132.04 mmol) as described above gave 2-(pentadec-2-ynyloxy)tetrahydro-2H-pyran (27.2 g, 80%) which was used without further purification. TLC: 10% EtOAc/hexanes, Rf≈0.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09272991B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-a16f454496e0484e9bebc993c6bf8143 |
| Source note | uspto-grants-2016_03 |