5,5-Dimethylpyrrolidine-2,4-dione → 8-Methoxy-3-phenyl-1-azaspiro[4.5]decane-2,4-dione

HRID 918993Notes

Reaction equation

HRID 918993 reaction equation
[CH3:1][O:2][CH:3]1[CH2:18][CH2:17][C:6]2([NH:10][C:9](=[O:11])[CH:8]([C:12](OC)=O)[C:7]2=[O:16])[CH2:5][CH2:4]1.[CH3:19][C:20]1(C)N[C:23](=O)[CH2:22][C:21]1=O>>[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][C:6]2([NH:10][C:9](=[O:11])[CH:8]([C:12]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:7]2=[O:16])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 133467095,5-Dimethylpyrrolidine-2,4-dioneHCID 70495212Methyl 8-methoxy-2,4-dioxo-1-azaspiro[4.5]decane-3-carboxylate

Product 1

HCID 704962318-Methoxy-3-phenyl-1-azaspiro[4.5]decane-2,4-dioneYield 90%

Procedure

The procedure is as in Example 1, except that 1.532 g of methyl 8-methoxy-2,4-dioxo-1-azaspiro[4.5]decane-3-carboxylate as in Example (X-2-a-1) are used instead of 5,5-dimethylpyrrolidine-2,4-dione. This gives the title compound in a yield of approximately 90% of theory.

Sources & evidence

ORD record
ord-5bb78c6211254566b3560cd839cfbf2c
Source dataset
uspto-grants-2016_03
Patent number
US09272997B2

Reaction notes

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