反应详情

A mixture of benzyl 4-(hydroxy-(4-methoxyphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1.679 g, 4.5 mmol) and amberlyst 15 (1.85 g) in MeOH (20 mL) was stirred at room temperature for 2 days. The mixture was centrifuged and the solid was washed with MeOH (2×40 mL). The solvent was removed to dryness and after purification by column chromatography (SiO2 using a mixture of CH2Cl2/EtOAc) the product was obtained as a white solid (1.26 g, 84% yield).

1. washthe solid was washed with MeOH (2×40 mL)
2. customThe solvent was removed to dryness
3. customafter purification by column chromatography (SiO2 using
4. additiona mixture of CH2Cl2/EtOAc) the product