HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → Benzene, ((2-bromoethoxy)methyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | 1-Propanol | HCID 1031 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Umeclidinium bromide | HCID 11519069 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Benzene, ((2-bromoethoxy)methyl)- | HCID 73833 | — |
Reaction Steps
In one aspect, the alcohol used in the preparation of umeclidinium bromide may be, for example, any isomer of propanol or butanol, such as n-propanol. Alternatively, the reaction may be performed in the presence of a dipolar aprotic solvent, which has a boiling point greater than 90° C., including but not limited to, DMF, DMA, DMSO or NMP.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273001B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-adbae32ffc5648bfabcd939ef6e6a6b0 |
| Source note | uspto-grants-2016_03 |