Phosgene → HCID 67957737, compound

Participants

Reaction Conditions

Reaction Steps

3-Bromo-pyridin-4-ylamine (0.55 g, 3.2 mmol) was dissolved in toluene (2 mL) then Hünig's base (1.1 mL, 6.4 mmol) and phosgene (1.9M in toluene, 1.8 mL, 3.5 mmol) were added. 1-(2-Chloro-phenyl)-ethanol (0.5 g, 3.2 mmol) in toluene (3 mL) was added and the reaction was heated to 100° C. for 2.5 hours, when no starting material remained by analytical LCMS. The reaction was submitted to EtOAc/H2O workup then purified via silica gel chromatography to provide the title compound.

Provenance & Evidence