HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Boronophenyl)cyclopropane-1-carboxylic acid → 1-(4'-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-pyridin-3-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Boronophenyl)cyclopropane-1-carboxylic acid | HCID 46739666 | — |
| Reactant | Trifluoro-methanesulfonic acid 4-{4-[1-(2-chloro-phenyl)-ethoxycarbonylamino]-pyridin-3-yl}-phenyl ester | HCID 86697086 | — |
| Product | 1-(4'-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-pyridin-3-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid | HCID 57336785 | — |
Reaction Steps
Prepared according to the procedure described in Example 1, Step 2, using the following starting materials: trifluoro-methanesulfonic acid 4-{4-[1-(2-chloro-phenyl)-ethoxycarbonylamino]-pyridin-3-yl}-phenyl ester and 1-(4-boronophenyl)cyclopropanecarboxylic acid. After workup the crude material was purified via preparatory HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09272990B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-dcc8cb49b3da443295dde26d5eb7012b |
| Source note | uspto-grants-2016_03 |