HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 919047Generated: October 30, 2026
Lithium Hydroxide → 5-(4-Bromophenyl)oxazole-4-carboxylic acid
https://huagongshe.com/reaction/919047
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl 5-(4-bromophenyl)oxazole-4-carboxylate | HCID 2758809 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 5-(4-Bromophenyl)oxazole-4-carboxylic acid | HCID 61637413 | — |
Reaction Steps
5-(4-Bromo-phenyl)-oxazole-4-carboxylic acid ethyl ester (1.0 g, 3.4 mmol) was dissolved in MeOH:H2O (5:1, 60 mL) and then lithium hydroxide (1.0 g, 41.8 mmol) was added. The reaction was heated to 60° C. for 10 minutes then allowed to cool. The reaction was submitted to acidic aqueous/CH2Cl2 workup then concentrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09272990B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-c16d6bb7c8324ea0a6d92a7ae523c21b |
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| Source note | uspto-grants-2016_03 |
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