Methanol → (1-{4'-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid

Participants

Reaction Steps

(1-{4′-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid ethyl ester (0.240 g, 0.475 mmol) was dissolved in THF (5 mL), MeOH (2 mL) and H2O (2 mL) then lithium hydroxide monohydrate (0.100 g, 2.38 mmol) was added. The reaction was stirred overnight at room temperature. The reaction was submitted to standard aqueous workup then triturated with CH2Cl2:hexanes to afford the product as a solid that was recovered by filtration.

Provenance & Evidence