HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 919083Generated: October 25, 2026
Sodium hydride → (4-Bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amine
https://huagongshe.com/reaction/919083
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-1-methyl-1H-pyrazol-5-amine | HCID 600351 | — |
| Reactant | 2-Chloro-6-phenylpyridine | HCID 2762880 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amine | HCID 67957971 | — |
Reaction Steps
4-Bromo-2-methyl-2H-pyrazol-3-ylamine (0.2 g, 1.14 mmol) and 2-chloro-6-phenyl-pyridine (0.32 g, 1.7 mmol) were dissolved in DMF (5 mL) then sodium hydride (60% dispersion in oil, 0.09 g, 2.3 mmol) was added. The reaction was heated to 100° C. for 30 minutes then cooled and submitted to standard aqueous workup. The residue was purified on silica gel (0-40% EtOAc in hexanes) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09272990B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-340d5ce61ccc4681a4beb6c20494da88 |
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| Source note | uspto-grants-2016_03 |
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