1-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester → HCID 67959563, compound

HRID 919094Notes

Reaction equation

HRID 919094 reaction equation
Br[C:2]1[CH:6]=[N:5][N:4]([CH2:7][CH3:8])[C:3]=1[CH:9]([OH:19])[CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH2:20]([O:22][C:23]([C:25]1([C:28]2[CH:33]=[CH:32][C:31]([C:34]3[CH:39]=[CH:38][C:37](B4OC(C)(C)C(C)(C)O4)=[CH:36][CH:35]=3)=[CH:30][CH:29]=2)[CH2:27][CH2:26]1)=[O:24])[CH3:21]>>[CH2:20]([O:22][C:23]([C:25]1([C:28]2[CH:29]=[CH:30][C:31]([C:34]3[CH:35]=[CH:36][C:37]([C:2]4[CH:6]=[N:5][N:4]([CH2:7][CH3:8])[C:3]=4[CH:9]([OH:19])[CH2:10][CH2:11][CH2:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[CH:38][CH:39]=3)=[CH:32][CH:33]=2)[CH2:27][CH2:26]1)=[O:24])[CH3:21]

Participants

3

Reactant 2

HCID 679580391-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 67963767HCID 67963767, compound

Product 1

HCID 67959563HCID 67959563, compound

Procedure

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: 1-(4-bromo-2-ethyl-2H-pyrazol-3-yl)-4-phenyl-butan-1-ol and 1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3667ab32c79b499ca75dc6b7712ff01a
Source dataset
uspto-grants-2016_03
Patent number
US09272990B2

Reaction notes

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