Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ciclopirox | HCID 2749 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54760963 | HCID 54760963 | — |
Reaction Steps
To 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one (0.5 g) in CH2Cl2 (20 mL) were added DMAP (0.44 g) and PhCOCl (0.5 mL) at 7° C. After the mixture was stirred at 7° C. for 90 min, solvent was partially removed in vacuum. Water (20 mL) and ethyl acetate (20 mL) were added. The organic layer was collected and concentrated. The desired compound was recrystallized from ethyl acetate and petroleum ether to yield compound 338 (0.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273005B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-7517e6413e6a43d9ba83584015c8cf42 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
