HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)benzoate → Ethyl 2-(2-amino-3-phenylpropanoyloxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)benzoate | HCID 67173975 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | Ethyl 2-(2-amino-3-phenylpropanoyloxy)benzoate | HCID 59193288 | 69.3% |
Reaction Steps
The ethyl 2-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)benzoate (1.2 g, 2.9 mmol) was dissolved in CH2Cl2 (10 mL) and TFA (4 mL). The reaction was stirred (RT, 3 h) and then concentrated. The crude material was purified by silica chromatography (0-10% MeOH/CH2Cl2) to afford 0.63 g of ethyl 2-(2-amino-3-phenylpropanoyloxy)benzoate. Mass calculated for C18H19NO4=313.35. found: [M+H]+=314.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09272984B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-703effadca0843a981a6d8ce391f45a7 |
| Source note | uspto-grants-2016_03 |