3-phenyl-2,1-benzoxazole → HCID 14528215, compound

HRID 919174Notes

Reaction equation

HRID 919174 reaction equation
[C:1]1([C:7]2O[N:10]=[C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO[CH:18]1[NH:22]C(=O)[N:20]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:19]1=[O:30]>Cl[Ti](Cl)(Cl)Cl.O1CCOCC1>[C:1]1([C:7]2[C:8]3[C:9](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:18]([C:19]([NH:20][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:30])[N:22]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 34608333-phenyl-2,1-benzoxazoleHCID 13258376HCID 13258376, compound

Product 1

HCID 14528215HCID 14528215, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 312751,4-DioxaneSolvent

Procedure

The reaction between 3-phenylbenzo[c]isoxazole and 5-methoxy-3-phenyl-2,4-imidazolidinedione in refluxing dioxane containing TiCl4 as catalyst to give 82% of 4,N-diphenyl-2-quinazolinecarboxamide [39];

Sources & evidence

ORD record
ord-fadd57bf279a4dc2b46c6e7034d9c477
Source dataset
uspto-grants-2016_03
Patent number
US09273012B2

Reaction notes

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